RLE Group
RLE Group is a biotech startup with a mission to develop bioengineering solutions for healthy life extension. Founded by the scientist who proposed the 10th hallmark of aging and a group of biohackers known for their experiment to translate therapeutic plasma exchange on human beings.
Extend Life
radically
radically
RLE Group
Extend Life
radically
radically
RLE Group is a biotech startup with a mission to develop bioengineering solutions for healthy life extension.
RLE Group
RLE Group is a biotech startup with a mission to develop bioengineering solutions for healthy life extension. Founded by the scientist who proposed the 10th hallmark of aging and a group of biohackers known for their experiment to translate therapeutic plasma exchange on human beings.
Extend Life
radically
radically
RLE Group
Extend Life
radically
radically
RLE Group is a biotech startup with a mission to develop bioengineering solutions for healthy life extension. Founded by the scientist who proposed the 10th hallmark of aging and a group of biohackers known for their experiment to translate therapeutic plasma exchange on human beings.
Our Projects
Longevity gene delivery system
Safe and efficient gene delivery system based on a non-viral vector and silicon nanoparticles for gene therapy of aging. With the help of this system we could deliver a combination of several genes each of which extended lifespan of mice by up to 40%.
We developed a compound only several injections of which are capable of extending a lifespan of already aged mice by more than 10% by rejuvenating epigenetic signature of aged blood stems cells.
Restoration of Elastin
We are developing a genetic vector carrying all genes that are necessary for elastogenesis. This vector in conjunction with our gene delivery system will help to return elasticity to aged skin and potentially could be used to restore elasticity of other organs and tissues like heart, lungs and blood vessels.
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Epigenetic rejuvenation
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Our Projects
With the help of this system we could deliver a combination of several genes each of which extended lifespan of mice by up to 40%.
Safe and efficient gene delivery system based on a non-viral vector and silicon nanoparticles for gene therapy of aging.
Project 1
Longevity gene delivery system
Project 2
We developed a compound only several injections of which are capable of extending a lifespan of already aged mice by more than 10% by rejuvenating epigenetic signature of aged blood stems cells.
Epigenetic rejuvenation
This vector in conjunction with our gene delivery system will help to return elasticity to aged skin and potentially could be used to restore elasticity of other organs and tissues like heart, lungs and blood vessels.
We are developing a genetic vector carrying all genes that are necessary for elastogenesis.
Project 3
Restoration of Elastin
to get more details
to get more details
Our Team
nikolai sidorov
CSO
Alexander Fedintsev, MSc
Stanislav polozov, MSc
Director, Intellectual Property
Investor, Board Member
Core Members of the RLE group
Scientific advisers
CEO
Yuri Khait, MSc
leonid peshkin, PhD
aleksei moskalev, PhD
Biogerontologist, professor at Harvard Medical School
Biogerontologist with 20+ years experience in Ageing Research
leonid peshkin, PhD
aleksei moskalev, PhD
Biogerontologist, professor at Harvard Medical School
Biogerontologist with 20+ years experience in Ageing Research
CO-Founder
Investor, Board Member
Director, Intellectual Property
Stanislav polozov, MSc
Alexander Fedintsev, MSc
CSO
nikolai sidorov
CEO
Yuri Khait, MSc
Andrei Isaev, MD
Our Team
Core Members of the RLE group
Scientific advisers
Andrei Isaev, MD
Yuri Khait, MSc
dmitrii sosin, PhD
nikolai sidorov
Alexander Fedintsev, MSc
Stanislav polozov, MSc
aleksei moskalev, PhD
leonid peshkin, PhD
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Principal Research Scientist
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Dmitrii Sosin, PhD
Principal Research Scientist
dmitrii sosin, PhD
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Scientific Publications
The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.
4.931 (2021)
Five year impact factor
Five year impact factor
Circadian clock genes’ overexpression in Drosophila alters diet impact on lifespan.
5.585 (2021)
Five year impact factor
Five year impact factor
The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor.
7.886 (2021)
Five year impact factor
Five year impact factor
11.005
Impact Factor
Impact Factor
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.
Aging cell, 15(3), 407-415
Mar, 2016
Aging (Albany NY), 9(4), 1280
5.955
Impact Factor
Impact Factor
Apr, 2017
Markers of arterial health could serve as accurate non-invasive predictors of human biological and chronological age.
11.788
Impact Factor
Impact Factor
Stochastic non-enzymatic modification of long-lived macromolecules-A missing hallmark of aging.
Dec, 2016
BMC genomics, 17(14), 273-289
Biogerontology 20, 159–170
Apr, 2019
Antioxidants 2020, 9, 1239
Dec, 2020
Ageing Research Reviews, 62, 101097
Sep, 2020
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Scientific Publications
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Ageing Research Reviews, 62, 101097
Sep, 2020
11.788 Impact Factor
Stochastic non-enzymatic modification of long-lived macromolecules-A missing hallmark of aging.
READ MORE
5.955 Impact Factor
Aging (Albany NY), 9(4), 1280
Apr, 2017
Markers of arterial health could serve as accurate non-invasive predictors of human biological and chronological age.
READ MORE
11.005 Impact Factor
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.
Aging cell, 15(3), 407-415
Mar, 2016
READ MORE
4.931 (2021) 5 year impact factor
The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.
Dec, 2016
BMC genomics, 17(14), 273-289
READ MORE
Circadian clock genes’ overexpression in Drosophila alters diet impact on lifespan.
Biogerontology 20, 159–170
Apr, 2019
5.585 (2021) 5 year impact factor
Antioxidants 2020, 9, 1239
Dec, 2020
7.886 (2021) 5 year impact factor
READ MORE
The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to
the Stress Factor.
the Stress Factor.
Scientific Publications
The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor.
Antioxidants 2020, 9, 1239
Dec, 2020
7.886 (2021) 5 year impact factor
READ MORE
READ MORE
Ageing Research Reviews, 62, 101097
Sep, 2020
11.788 Impact Factor
Stochastic non-enzymatic modification of long-lived macromolecules-A missing hallmark of aging.
READ MORE
5.955 Impact Factor
Aging (Albany NY), 9(4), 1280
Apr, 2017
Markers of arterial health could serve as accurate non-invasive predictors of human biological and chronological age.
READ MORE
4.931 (2021) 5 year impact factor
The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.
Dec, 2016
BMC genomics, 17(14), 273-289
READ MORE
Circadian clock genes’ overexpression in Drosophila alters diet impact on lifespan.
Biogerontology 20, 159–170
Apr, 2019
5.585 (2021) 5 year impact factor
READ MORE
11.005 Impact Factor
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.
Aging cell, 15(3), 407-415
Mar, 2016
The Resistance of Drosophila melanogaster to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor.
Antioxidants 2020, 9, 1239
Dec, 2020
7.886 (2021) 5 year impact factor
READ MORE
READ MORE
Ageing Research Reviews, 62, 101097
Sep, 2020
11.788 Impact Factor
Stochastic non-enzymatic modification of long-lived macromolecules-A missing hallmark of aging.
READ MORE
5.955 Impact Factor
Aging (Albany NY), 9(4), 1280
Apr, 2017
Markers of arterial health could serve as accurate non-invasive predictors of human biological and chronological age.
READ MORE
11.005 Impact Factor
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.
Aging cell, 15(3), 407-415
Mar, 2016
READ MORE
4.931 (2021) 5 year impact factor
The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions.
Dec, 2016
BMC genomics, 17(14), 273-289
READ MORE
Circadian clock genes’ overexpression in Drosophila alters diet impact on lifespan.
Biogerontology 20, 159–170
Apr, 2019
5.585 (2021) 5 year impact factor
Media about us
Another article about our experiment of translating therapeutic plasma exchange from mice to humans.
Our team was the first to try therapeutic plasma exchange on humans. We tried it on ourselves, measured various biomarkers and noticed some positive changes. More details are in the article.
A recent article in “Fortune” magazine about
the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key driver of aging.
the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key driver of aging.
Media Coverage
Out for blood in the search to stall aging.
A gaggle of biotech start-ups are trying vastly different approaches to spin animal studies into the next big anti-aging therapy. It’s too early to know which, if any, will succeed.
A recent article in “Fortune” magazine about the prospects for overcoming aging fortune.com/2020/12/30/ anti-aging-research-health-care-spending-biden refers, among others, to the work of our group member A.Fedintsev, where one of the main causes of aging is damage to long-lived proteins of the extracellular matrix.
One of the main causes of aging.
About our experiment: Biohackers Perform First Plasma Dilution Experiment on Humans. A recent article in “Fortune” magazine about the prospects for overcoming aging fortune.com/2020/12/30/ anti-aging-research-health-care-spending-biden refers, among others, to the work of our group member A.Fedintsev, where one of the main causes of aging is damage to long-lived proteins of the extracellular matrix.
Plasma Dilution Experiment on Humans.
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Another article about our experiment of translating therapeutic plasma exchange from mice to humans.
READ MORE
READ MORE
One of the main causes of aging.
A recent article in “Fortune” magazine about the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key driver of aging.
READ MORE
READ MORE
Plasma Dilution Experiment on Humans.
Our team was the first to try therapeutic plasma exchange on humans. We tried it on ourselves, measured various biomarkers and noticed some positive changes. More details are in the article.
READ MORE
READ MORE
Our CSO A. Fedintsev at Foresight Institute talks about biohacking and why it is an important component of a strategy for radical life extension.
Biohacking – A Necessary Component of a Strategy for Radical Life Extension - Foresight Institute.
Out for blood in the search to stall aging.
READ MORE
READ MORE
Another article about our experiment of translating therapeutic plasma exchange from mice to humans.
Media Coverage
Another article about our experiment of translating therapeutic plasma exchange from mice to humans.
Our team was the first to try therapeutic plasma exchange on humans. We tried it on ourselves, measured various biomarkers and noticed some positive changes. More details are in the article.
A recent article in “Fortune” magazine about the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key driver of aging.
Our CSO A. Fedintsev at Foresight Institute talks about biohacking and why it is an important component of a strategy for radical life extension.
One of the main causes of aging.
Plasma Dilution Experiment on Humans.
Biohacking – A Necessary Component of a Strategy for Radical Life Extension - Foresight Institute.
Out for blood in the search to stall aging.
READ MORE
READ MORE
READ MORE
READ MORE
Media Coverage
READ MORE
One of the main causes of aging.
A recent article in “Fortune” magazine about
the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key
driver of aging.
the prospects for overcoming aging refers, among others, to the work of our CSO A.Fedintsev, where he proposes the 10th hallmark of aging and claims that damage to long-lived proteins of the extracellular matrix may be a key
driver of aging.
READ MORE
Plasma Dilution Experiment on Humans.
Our team was the first to try therapeutic plasma exchange on humans. We tried it on ourselves, measured various biomarkers and noticed some positive changes. More details are in the article.
Biohacking – A Necessary Component of a Strategy for Radical Life Extension - Foresight Institute.
Our CSO A. Fedintsev at Foresight Institute talks about biohacking and why it is an important component of a strategy for radical life extension.
READ MORE
Out for blood in the search to stall aging.
Another article about our experiment of translating therapeutic plasma exchange from mice to humans.
READ MORE